FOR SEX-SPECIFIC PRECISION MEDICINE
The Aguado iBiomaterials Research Group
The vision of the Aguado iBiomaterials Research Group is to develop personalized biomaterials as tools to evaluate a patient’s unique biology to treat disease based on sex, age, and/or ancestry. We will first focus on sex as a biological variable and investigate mechanisms governing sex differences in cardiovascular diseases.
Brandon Vogt's original research article is published in Biomaterials Science and featured on the back cover
October 7, 2022
Congratulations to Brandon for publishing his work on how inflammatory serum factors from aortic valve stenosis patients drive sex-specific valvular cell phenotypes!
Congratulations to Talia, Rayyan, and Nicole!
August 10, 2022
Warmest congratulations to Talia Baddour, Rayyan Gorashi, and Nicole Félix-Vélez for passing their 1st year qualifying exams in the Bioengineering department!
Rayyan Gorashi and Steven Robles present at the BIC Symposium in Santa Barbara
August 9, 2022
Rayyan Gorashi and Steven Robles presented posters at the annual BIC Symposium, hosted by UC Santa Barbara!
Happy 1st Anniversary to the Aguado Lab!
July 1, 2022
Check out our Twitter post highlighting our greatest accomplishments in the past year! To celebrate, we all took the day off for a boat ride around Mission Bay!
Welcome to Steven Robles!
June 21, 2022
Warmest welcome to Steven Robles, summer REU student from the University of Florida! He will be working with Nicole Félix-Vélez to investigate the role of serum factors in regulating persistent myofibroblast activation.
Rayyan Gorashi presents at the EMBO-FEBS Lecture Course, "Molecular mechanisms of interorgan crosstalk in health and disease"
May 22, 2022
Congratulations to Rayyan for receiving an EMBO-FEBS Travel Award to present her research on how valvular interstitial cells respond to nano-scale stiffness cues in Spetses, Greece!
Brandon Vogt presents at the Society for Biomaterials annual meeting
April 28, 2022
Brandon presented his research on how aortic valve stenosis patient serum biomarkers regulate sex differences in valve myofibroblast activation and osteoblast-like differentiation at the biomaterials approaches to address health and healthcare disparities session.
Talia Baddour attends the AIMBE Public Policy Institute annual meeting
April 25, 2022
Congratulations to Talia for receiving an AIMBE Travel Award to attend the Public Policy Institute meeting in Washington, DC!
Aguado Lab receives the American Heart Association Career Development Award
March 25, 2022
The Aguado lab receives funding from the AHA to investigate the role of X chromosome dosage in regulating sex differences in valvular interstitial cells!
Brian interviewed for the Northwestern Intersections podcast
April 14, 2022
Check out Brian's interview with Northwestern Intersections on "Why It's Important to Bring Your Full Self to the Lab"!
Paper published in Circulation
January 10, 2022
Check out our latest work focused on understanding the role of genes that escape X chromosome inactivation in regulating sex-specific myofibroblast activation in VICs cultured on hydrogel biomaterials!
Bianca Peña starts Winter quarter rotation
January 4, 2022
Warmest welcome to Bianca Peña, 1st year PhD student in Bioengineering! Bianca will help launch our animal work in the lab to study sex differences in inflammation. Welcome, Bianca!
Aguado Lab featured in ThisWeek@UCSD
December 2, 2021
Thank you to ThisWeek@UCSD for profiling our lab's research on sex differences in cardiovascular disease, as well as our efforts in co-founding LatinXinBME!
Talia Baddour starts Fall quarter rotation
September 20, 2021
Another super warm welcome to Talia Baddour, recent Lafayette College graduate from the Mechanical Engineering department! Talia will be using spatial transcriptomics to understand sex differences in valve myofibroblast heterogeneities. Welcome, Talia!
Nicole Félix-Vélez starts Fall quarter rotation
September 12, 2021
Super excited to welcome Nicole Félix-Vélez, recent Cornell University graduate from the Biomedical Engineering department! Nicole will be researching sex differences in persistent myofibroblasts cultured on hydrogels. Welcome, Nicole!
Brian invited to serve on the Early Career Editorial Board for the Journal of Biomedical Materials - Part A
August 30, 2021
Brian will participate in the editing and review process for one of the leading journals in the biomaterials field.
Brandon Vogt starts his position as Staff Research Associate
August 9, 2021
Thrilled to welcome Brandon Vogt, recent CU Boulder graduate from the Chemical and Biological Engineering department! Brandon will be assisting with setting up the laboratory and helping manage our research in the laboratory. Welcome, Brandon!
The Aguado iBiomaterials Lab opens today!
July 1, 2021
Super excited to announce the Aguado iBiomaterials Lab is officially open! We are a part of the Bioengineering department at UC San Diego and the Sanford Consortium for Regenerative Medicine.
Paper published in the Journal Of Molecular And Cellular Cardiology
June 21, 2021
Cierra, Megan, and Brian worked together to write a comprehensive review on the current knowledge of sex differences in the cells of the heart. Check it out!
Paper published in Nature Biomedical Engineering
April 19, 2021
Congratulations to Cierra Walker and co-authors! Together, we explored the nuclear mechanosensing mechanisms that drive persistent myofibroblast activation.
Paper published in Nature Reviews Materials
October 20, 2020
LatinXinBME Co-founders Brian and Ana Porras published a Comment entitled "Building a virtual community to support and celebrate the success of Latinx scientists" in Nature Reviews Materials! Please contact us for an invitation to join our vibrant LatinXinBME community!
Brian selected for the Outstanding Postdoc Award at CU Boulder!
September 17, 2020
Brian is honored to be recognized with the Outstanding Postdoc Award at CU Boulder. Thank you to Kristi Anseth for your nomination!
Paper published in Arteriosclerosis, Thrombosis, and Vascular Biology
September 17, 2020
Check out our latest Research Article on "Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells!"
Brian named one of 100 Most Inspiring Hispanic/Latinx Scientists In America by Cell Press!
September 15, 2020
Brian is honored to have been named one of the 100 most inspiring Latinx scientists by Cell Press! He will continue his leadership efforts with LatinXinBME and build community among Latinx biomedical engineers and scientists. Be sure to check out the full list of inspiring scholars at the link below!
Brian joins Sanford Consortium For Regenerative Medicine!
September 15, 2020
Brian has joined the Sanford Consortium for Regenerative Medicine faculty! "The mission of Sanford Consortium for Regenerative Medicine is to advance stem cell research through collaborative, multi-disciplinary interactions. This “collaboratory” enables scientists from the La Jolla Institute for Allergy & Immunology, the Salk Institute for Biological Studies, the Sanford Burnham Prebys Medical Discovery Institute, Scripps Research, and the University of California, San Diego to work side by side in a facility specifically designed to achieve breakthrough discoveries."
Brian accepts faculty position at UC San Diego!
April 22, 2020
Brian will join the Department of Bioengineering as an Assistant Professor in the Jacobs School of Engineering at the University of California, San Diego! Brian will start his position in July of 2021.
Brian presents at SACNAS 2019
October 31, 2019
Brian gave an invited talk as part of the Burroughs Wellcome Fund Special Session entitled "Increasing Understanding of Diverse Scientific Approaches in Designing Therapeutic Solutions" at the SACNAS Annual Meeting in Honolulu, HI.
LatinXinBME meetup at BMES
October 17, 2019
Come join LatinXinBME at El Rey restaurant on Thursday, October 17 for a casual meet-up during the conference! Dr. Ana Maria Porras and I will be at the BMES registration table at 6:30 pm.
Brian presenting at BMES
October 14, 2019
Brian will be attending the annual BMES meeting in Philadelphia, PA this week! Check out his talk info below:
(1) Meet the Faculty Candidates Poster Session
Wednesday, October 16, 2019
3:30pm - 5:30pm in the Exhibit Hall
(2) Talk: Sex-specific Valvular Myofibroblast Activation on Engineered Hydrogel Substrates
Thursday, October 17, 2019
1:30 PM - 1:45 PM Room 118A
(3) Talk: Sex-specific Valvular Myofibroblast Activation in Response to Nano-scale Stiffness Cues
Thursday, October 17, 2019
3:45 PM - 4:00 PM Room 115A
(4) Talk: TAVR Alters Circulating Serum Factors to Mediate Valve and Cardiac Myofibroblast De-activation
Saturday, October 19, 2019
1:30 PM - 3:00 PM Room 120A
Paper published in Science Translational Medicine
September 11, 2019
CU Boulder engineers and faculty from the Consortium for Fibrosis Research & Translation (CFReT) at the CU Anschutz Medical Campus have teamed up to develop biomaterial-based “mimics” of heart tissues to measure patients’ responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue re-shapes itself post-surgery.
Brian visits the University of Washington - Distinguished Young Seminar Series
August 12, 2019
Brian presented his work on developing precision biomaterials for probing valvular fibroblast activation as part of the Distinguished Young Seminar Series at the University of Washington.
Brian receives NIH K99/R00 Career Transition Award
August 1, 2019
Brian's proposal entitled "Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substrates" was awarded funding from the NIH NHLBI!
Brian chairs Gordon Research Seminar in Biomaterials and Tissue Engineering
July 27, 2019
The Gordon Research Seminar and Conference in Biomaterials and Tissue Engineering took place on July 27 to August 2 in Castelldefels, Spain.