COVER GALLERY

Artwork by Brandon Vogt (Biomaterials Science), Katie Aguado (Nature BME, Science Translational Medicine), Steve Alvey (Advanced Healthcare Materials), and Alex Caldwell (Advanced Functional Materials)

PUBLICATIONS

Google Scholar - Brian Aguado

Y chromosome linked UTY modulates sex differences in valvular fibroblast methylation in response to nanoscale extracellular matrix cues

Gorashi RM, Baddour T, Chittle SJ, Félix Vélez NE, Wenning MA, Anseth KS, Mestroni L, Peña B, Guo P, Aguado BA. Science Advances. (2025).

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Secreted cytokines from inflammatory macrophages modulate sex differences in valvular interstitial cells on hydrogel biomaterials

Félix Vélez NE, Tu K, Guo P, Reeves RR, Aguado BA. Journal of Biomedical Materials Research Part A. (2025).

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Determining sex differences in drug combinations targeting aortic valve myofibroblast activation using an artificial intelligence derived platform

Vogt BJ, Wang P, Chavez M, Guo P, Chow EKH, Ho D, Aguado BA. bioRxiv. (2024).

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The future of sex and gender in research

Aguado BA, Jeffries DL, Jordan-Young R, Klein SL, Lett E, Stachenfeld N, Tollkuhn J, Xu X. Cell. (2024).

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Human fetal tissue is critical for biomedical research

Brumbaugh J, Aguado BA, Lysaght T, Goldstein LSB. Stem Cell Reports. (2023).

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Substrate stiffness modulates cardiac fibroblast activation, senescence and proinflammatory secretory phenotype

Felisbino MB, Rubino M, Travers JG, Schuetze KB, Lemieux ME, Anseth KS, Aguado BA, McKinsey TA. American Journal of Physiology: Heart and Circulatory Physiology. (2023).

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Equitable hiring strategies towards a diversified faculty

Cosgriff-Hernandez E, Aguado BA, Akpa BS, Fleming GC, Moore E, Porras AM, Boyle PM, Chan DD, Chesler N, Christman KL, Desai TA, Harley BAC, Killian ML, Maisel K, Maitland KC, Peyton SR, Puritt BL, Stabenfeldt SE, Stevens KR, Bowden A. Nature Biomedical Engineering (2023).

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Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation

Vogt BJ, Anseth KS, and Aguado BA. Biomaterials Science, Early Investigator Special Issue (2022).

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Precision biomaterials as tools to determine sex-specific mechanisms of cardiovascular disease

Vogt BJ and Aguado BA. Roadmap on Biomaterials for Women’s Health. Edited by Michelle Oyen and Kaitlin Fogg. IOP Science. JPhys Materials (2022).

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Chemical and molecular tools to probe sex differences in biology

Félix Vélez NE, Gorashi R, and Aguado BA. Journal of Materials Chemistry B, Early Investigator special issue (2022).

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The sex of your cells matter when it comes to heart disease

Aguado BA. The Conversation (2022).

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Genes that escape X chromosome inactivation modulate sex differences in valve myofibroblasts

Aguado BA, Walker CJ, Grim JC, Schroeder ME, Batan D, Vogt BJ, Gonzalez Rodriguez A, Schisow JA, Moulton KS, Weiss RM, Heistad DD, Leinwand LA, Anseth KS. Circulation (2022).

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Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

Walker CJ, Batan D, Bishop C, Ramirez R, Aguado BA, Schroeder ME, Crocini C, Schwisow JA, Moulton KS, Macdougall L, Weiss, RM, Allen M, Dowell R, Leinwand LA, Anseth KS. Bioengineering and Translational Medicine (2022).

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Hydrogel cultures reveal Transient Receptor Potential Vanilloid 4 regulation of myofibroblast activation and proliferation in valvular interstitial cells

Batan D, Peters DK, Schroeder ME, Aguado BA, Young MW, Weiss RM, Anseth KS. The FASEB Journal (2022).

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Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling

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Osteopontin activity modulates sex-specific calcification in engineered valve tissue mimics

Schroeder ME, Gonzalez Rodriguez A, Speckl KF, Peters DK, Walker CJ, Grim JC, Aguado BA, Weiss RM, Anseth KS. Bioengineering and Translational Medicine (2022).

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Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera

Rogers JD, Aguado BA, Watts KM, Anseth KS, Richardson WJ. PNAS (2022).

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Matters of the heart: cellular sex differences

Walker CJ, Schroeder ME, Aguado BA, Anseth KS, Leinwand LA. Journal of Molecular and Cellular Cardiology (2021)

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Nuclear mechanosensing drives chromatic remodeling of persistently activated myofibroblasts

Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. Nature Biomedical Engineering, doi.org/10.1038/s41551-021-00709-w (2021)

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Building a virtual community to support and celebrate the success of Latinx scientists

Aguado BA and Porras AM. Nature Reviews Materials, doi.org/10.1038/s41578-020-00259-8 (2020)

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Secreted factors from pro-inflammatory macrophages promote an osteoblast-like phenotype in valvular interstitial cells

JC Grim*, Aguado BA*, Vogt BJ, Batan D, Andrichik CL, Schroeder ME, Gonzalez-Rodriguez A, Yavitt FM, Weiss RM, Anseth KS. Arteriosclerosis, Thrombosis, and Vascular Biology, in press (2020). *indicates equal contribution.

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Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation

Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Science Translational Medicine, Accepted (2019).

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Designing microgels for controlled assembly of stem cell and tissue microenvironments

Caldwell AS, Aguado BA, Anseth KS. Advanced Functional Materials, 1907670 (2019)

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Gold nanoparticle functionalized reverse thermal gel for tissue engineering applications

Peña B, Maldonado M, Bonham A, Aguado BA, Dominguez-Alfaro A, Laughter, Melissa, Rowland T, Bardill J, Farnsworth N, Alegret-Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. ACS Applied Materials and Interfaces, 11(20), 18671-18680 (2019).

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A reversible and repeatable thiol-ene bioconjugation for dynamic patterning of signaling proteins in hydrogels

Grim JC, Brown TE, Aguado BA, Chapnick D, Viert A, Liu X, Anseth KS. ACS Central Science, 4(7), 909-916 (2018).

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Biomaterial scaffolds as pre-metastatic niche mimics systemically alter the primary tumor and tumor microenvironment

Aguado BA, Dudek RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD. Advanced Healthcare Materials, adhm.1700903 (2018). *Cover article for May 2018 issue

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Engineering precision biomaterials for personalized medicine

Aguado BA, Grim JC, Rosales AM, Watson-Capps JJ, Anseth KS. Science Translational Medicine, 10, eeam8645 (2018).

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Injectable carbon nanotube-functionalized reverse thermal gel promotes cardiomyocyte survival and maturation

Peña B, Bosi S, Aguado BA, Borin D, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. ACS Applied Materials and Interfaces, 9(37), 31645-31656 (2017).

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Engineering the pre-metastatic niche

Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD. Nature Biomedical Engineering, 1, 0077 (2017). *Cover article for June 2017 issue

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Enhanced survival with implantable scaffolds that capture metastatic breast cancer cells in vivo

Rao SS, Azarin SM, Spicer G, Bushnell GG, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, and Jeruss JS. Cancer Research, 76(18), 5209-5218 (2016).

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Extracellular matrix mediators of metastatic cell colonization identified using scaffold mimics of the pre-metastatic niche

Aguado BA, Caffe JR, Rao SS, Bushnell GG, Azarin SM, and Shea LD. Acta Biomaterialia, 33, 13-24 (2016).

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Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes

Dubash AD*, Kam CY*, Aguado BA, Patel D, Delmar M, Shea LD, Green KJ. Journal of Cell Biology, 15, 212(4), 425-438 (2016).

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Secretome identification of immune cell factors mediating metastatic cell homing

Aguado BA, Wu JJ, Azarin SM, Nanavati D, Rao SS, Bushnell GG, Medicherla CB, and Shea LD. Scientific Reports, 5, 17566; DOI: 10.1038/srep17566 (2015).

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In vivo capture and label-free detection of early metastatic cells

Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Backman V, Jeruss JS, and Shea LD. Nature Communications, 8(6), 8094; DOI: 10.1038/ncomms9094 (2015).

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In vivo acute and humoral response to three-dimensional porous soy protein scaffolds

Chien KB, Aguado BA, Bryce PJ, and Shah RN. Acta Biomaterialia, 9(11), 8983-8990 (2013).

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Osteogenic potential of BMP-2 releasing self-assembled membranes

Chung EJ, Chien KB, Aguado BA, and Shah RN. Tissue Engineering: Part A, 19(23-24), 2664-73 (2013).

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Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers

Aguado BA, Mulyasasmita W, Su J, Lampe KJ, and Heilshorn SC. Tissue Engineering: Part A, 18(7-8), 806-815 (2012).

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Optimization of hydrogel viscoelasticity to improve transplanted cell viability

Aguado BA and Heilshorn SC. Polymer Preprints, 51(1), 670-671 (2010).

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